Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
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ABSTRACT:
SUBMITTER: Hu MC
PROVIDER: S-EPMC3770142 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
Hu Ming Chang MC Shiizaki Kazuhiro K Kuro-o Makoto M Moe Orson W OW
Annual review of physiology 20130101
The metabolically active and perpetually remodeling calcium phosphate-based endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and phosphate homeostasis that involves multiple organs in terms of mineral flux and endocrine cross talk. The fibroblast growth factor (FGF)-Klotho endocrine networks epitomize the complexity of systems biology, and specifically, the FGF23-αKlotho axis highlights the concept of the skeleton holding the master switch of homeostasis rather ...[more]
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