Ontology highlight
ABSTRACT:
SUBMITTER: Ortega Roldan JL
PROVIDER: S-EPMC3770644 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ortega Roldan Jose L JL Casares Salvador S Ringkjøbing Jensen Malene M Cárdenes Nayra N Bravo Jerónimo J Blackledge Martin M Azuaga Ana I AI van Nuland Nico A J NA
PloS one 20130911 9
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 domain and ubiquitin and performed a structural and mutational analysis to decipher the determinants of the SH3-C binding mode to ubiquitin. We found that the Phe-to-Tyr mutation in CD2AP and in the homologous CIN85 SH3-C domain does not abrogate ubiqui ...[more]