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High anti-Cryptosporidium parvum IgG seroprevalence in HIV-infected adults in Limpopo, South Africa.


ABSTRACT: A seroepidemiological study was performed to determine the seroprevalence of Cryptosporidium in human immunodeficiency virus (HIV)-infected adults and local university students in the Limpopo Province, South Africa. Using a custom anti-C. parvum immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA), the seroprevalence of Cryptosporidium was found to be significantly higher (75.3%; 146 of 193) in HIV-infected individuals compared with student volunteers (32.8%; 19 of 58) (P < 0.001). A more recent diagnosis of HIV was associated with anti-C. parvum IgG seropositivity, as was lower weight among HIV-infected women. This is the first seroepidemiologic study of Cryptosporidium in rural South Africa, and it shows high endemicity among the HIV-infected population. In addition to raising the possibility of significant Cryptosporidium-related morbidities, this finding reveals that in Limpopo and perhaps in other low-income, rural populations, interrupting waterborne pathogen transmission will require strategies effective against environmentally hardy parasites such as Cryptosporidium.

SUBMITTER: Bartelt LA 

PROVIDER: S-EPMC3771295 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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High anti-Cryptosporidium parvum IgG seroprevalence in HIV-infected adults in Limpopo, South Africa.

Bartelt Luther A LA   Sevilleja Jesus Emmanuel JE   Barrett Leah J LJ   Warren Cirle A CA   Guerrant Richard L RL   Bessong Pascal O PO   Dillingham Rebecca R   Samie Amidou A  

The American journal of tropical medicine and hygiene 20130708 3


A seroepidemiological study was performed to determine the seroprevalence of Cryptosporidium in human immunodeficiency virus (HIV)-infected adults and local university students in the Limpopo Province, South Africa. Using a custom anti-C. parvum immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA), the seroprevalence of Cryptosporidium was found to be significantly higher (75.3%; 146 of 193) in HIV-infected individuals compared with student volunteers (32.8%; 19 of 58) (P < 0.001). A  ...[more]

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