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Thiamin biosynthesis: still yielding fascinating biological chemistry.

ABSTRACT: The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

SUBMITTER: Begley TP

PROVIDER: S-EPMC3771315 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Thiamin biosynthesis: still yielding fascinating biological chemistry.

Begley Tadhg P TP Ealick Steven E SE McLafferty Fred W FW

Biochemical Society transactions 20120601 3

The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase. ...[more]

PMID: 22616866

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Biosynthesis of Thiamin Pyrophosphate.

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