Ontology highlight
ABSTRACT:
SUBMITTER: Chatterjee A
PROVIDER: S-EPMC6040654 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Chatterjee Abhishek A Schroeder Frank C FC Jurgenson Christopher T CT Ealick Steven E SE Begley Tadhg P TP
Journal of the American Chemical Society 20080725 34
Thiamin thiazole biosynthesis in eukaryotes is still not completely understood. In this report, a late intermediate, tightly bound to the active site of the Saccharomyces cerevisiae thiazole synthase, was identified as an adenylated thiazole tautomer. The reactivity of this unusual compound was evaluated. Its identification provides an additional molecular snapshot of the complex reaction sequence catalyzed by the eukaryotic thiazole synthase and identifies the final step of the thiamin-thiazole ...[more]