Functional lipids and lipoplexes for improved gene delivery.
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ABSTRACT:
SUBMITTER: Zhang XX
PROVIDER: S-EPMC3771368 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Functional lipids and lipoplexes for improved gene delivery.
Zhang Xiao-Xiang XX McIntosh Thomas J TJ Grinstaff Mark W MW
Biochimie 20110520 1
Cationic lipids are the most common non-viral vectors used in gene delivery with a few currently being investigated in clinical trials. However, like most other synthetic vectors, these vectors suffer from low transfection efficiencies. Among the various approaches to address this challenge, functional lipids (i.e., lipids responding to a stimuli) offer a myriad of opportunities for basic studies of nucleic acid-lipid interactions and for in vitro and in vivo delivery of nucleic acid for a speci ...[more]
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