Tri-peptide cationic lipids for gene delivery.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC4285367 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Tri-peptide cationic lipids for gene delivery.
Zhao Yinan Y Zhang Shubiao S Zhang Yuan Y Cui Shaohui S Chen Huiying H Zhi Defu D Zhen Yuhong Y Zhang Shufen S Huang Leaf L
Journal of materials chemistry. B 20150101 1
Several novel tri-peptide cationic lipids were designed and synthesized for delivering DNA and siRNA. They have tri-lysine and tri-ornithine as head groups, carbamate group as linker and 12 and 14 carbon atom alkyl groups as tails. These tri-peptide cationic lipids were prepared into cationic liposomes for the study of the physicochemical properties and gene delivery. Their particle size, Zeta potential and DNA-binding were characterized to show that they were suitable for gene transfection. The ...[more]
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