Cytokines are systemic effectors of lymphatic function in acute inflammation.
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ABSTRACT:
SUBMITTER: Aldrich MB
PROVIDER: S-EPMC3771384 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
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Cytokines are systemic effectors of lymphatic function in acute inflammation.
Aldrich Melissa B MB Sevick-Muraca Eva M EM
Cytokine 20130610 1
The response of the lymphatic system to inflammatory insult and infection is not completely understood. Using a near-infrared fluorescence (NIRF) imaging system to noninvasively document propulsive function, we noted the short-term cessation of murine lymphatic propulsion as early as 4h following LPS injection. Notably, the effects were systemic, displaying bilateral lymphatic pumping cessation after a unilateral insult. Furthermore, IL-1β, TNF-α, and IL-6, cytokines that were found to be elevat ...[more]
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