Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity.
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ABSTRACT:
SUBMITTER: Torrisi JS
PROVIDER: S-EPMC4726274 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity.
Torrisi Jeremy S JS Hespe Geoffrey E GE Cuzzone Daniel A DA Savetsky Ira L IL Nitti Matthew D MD Gardenier Jason C JC García Nores Gabriela D GD Jowhar Dawit D Kataru Raghu P RP Mehrara Babak J BJ
Scientific reports 20160122
Although recent studies have shown that obesity decreases lymphatic function, the cellular mechanisms regulating this response remain unknown. In the current study, we show that obesity results in perilymphatic accumulation of inflammatory cells and that local inhibition of this response with topical tacrolimus, an inhibitor of T cell differentiation, increases lymphatic vessel density, decreases perilymphatic iNOS expression, increases lymphatic vessel pumping frequency, and restores lymphatic ...[more]
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