Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.
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ABSTRACT:
SUBMITTER: Ferreira MA
PROVIDER: S-EPMC6465407 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.
Ferreira Manuel A MA Gamazon Eric R ER Al-Ejeh Fares F Aittomäki Kristiina K Andrulis Irene L IL Anton-Culver Hoda H Arason Adalgeir A Arndt Volker V Aronson Kristan J KJ Arun Banu K BK Asseryanis Ella E Azzollini Jacopo J Balmaña Judith J Barnes Daniel R DR Barrowdale Daniel D Beckmann Matthias W MW Behrens Sabine S Benitez Javier J Bermisheva Marina M Białkowska Katarzyna K Blomqvist Carl C Bogdanova Natalia V NV Bojesen Stig E SE Bolla Manjeet K MK Borg Ake A Brauch Hiltrud H Brenner Hermann H Broeks Annegien A Burwinkel Barbara B Caldés Trinidad T Caligo Maria A MA Campa Daniele D Campbell Ian I Canzian Federico F Carter Jonathan J Carter Brian D BD Castelao Jose E JE Chang-Claude Jenny J Chanock Stephen J SJ Christiansen Hans H Chung Wendy K WK Claes Kathleen B M KBM Clarke Christine L CL Couch Fergus J FJ Cox Angela A Cross Simon S SS Czene Kamila K Daly Mary B MB de la Hoya Miguel M Dennis Joe J Devilee Peter P Diez Orland O Dörk Thilo T Dunning Alison M AM Dwek Miriam M Eccles Diana M DM Ejlertsen Bent B Ellberg Carolina C Engel Christoph C Eriksson Mikael M Fasching Peter A PA Fletcher Olivia O Flyger Henrik H Friedman Eitan E Frost Debra D Gabrielson Marike M Gago-Dominguez Manuela M Ganz Patricia A PA Gapstur Susan M SM Garber Judy J García-Closas Montserrat M García-Sáenz José A JA Gaudet Mia M MM Giles Graham G GG Glendon Gord G Godwin Andrew K AK Goldberg Mark S MS Goldgar David E DE González-Neira Anna A Greene Mark H MH Gronwald Jacek J Guénel Pascal P Haiman Christopher A CA Hall Per P Hamann Ute U He Wei W Heyworth Jane J Hogervorst Frans B L FBL Hollestelle Antoinette A Hoover Robert N RN Hopper John L JL Hulick Peter J PJ Humphreys Keith K Imyanitov Evgeny N EN Isaacs Claudine C Jakimovska Milena M Jakubowska Anna A James Paul A PA Janavicius Ramunas R Jankowitz Rachel C RC John Esther M EM Johnson Nichola N Joseph Vijai V Karlan Beth Y BY Khusnutdinova Elza E Kiiski Johanna I JI Ko Yon-Dschun YD Jones Michael E ME Konstantopoulou Irene I Kristensen Vessela N VN Laitman Yael Y Lambrechts Diether D Lazaro Conxi C Leslie Goska G Lester Jenny J Lesueur Fabienne F Lindström Sara S Long Jirong J Loud Jennifer T JT Lubiński Jan J Makalic Enes E Mannermaa Arto A Manoochehri Mehdi M Margolin Sara S Maurer Tabea T Mavroudis Dimitrios D McGuffog Lesley L Meindl Alfons A Menon Usha U Michailidou Kyriaki K Miller Austin A Montagna Marco M Moreno Fernando F Moserle Lidia L Mulligan Anna Marie AM Nathanson Katherine L KL Neuhausen Susan L SL Nevanlinna Heli H Nevelsteen Ines I Nielsen Finn C FC Nikitina-Zake Liene L Nussbaum Robert L RL Offit Kenneth K Olah Edith E Olopade Olufunmilayo I OI Olsson Håkan H Osorio Ana A Papp Janos J Park-Simon Tjoung-Won TW Parsons Michael T MT Pedersen Inge Sokilde IS Peixoto Ana A Peterlongo Paolo P Pharoah Paul D P PDP Plaseska-Karanfilska Dijana D Poppe Bruce B Presneau Nadege N Radice Paolo P Rantala Johanna J Rennert Gad G Risch Harvey A HA Saloustros Emmanouil E Sanden Kristin K Sawyer Elinor J EJ Schmidt Marjanka K MK Schmutzler Rita K RK Sharma Priyanka P Shu Xiao-Ou XO Simard Jacques J Singer Christian F CF Soucy Penny P Southey Melissa C MC Spinelli John J JJ Spurdle Amanda B AB Stone Jennifer J Swerdlow Anthony J AJ Tapper William J WJ Taylor Jack A JA Teixeira Manuel R MR Terry Mary Beth MB Teulé Alex A Thomassen Mads M Thöne Kathrin K Thull Darcy L DL Tischkowitz Marc M Toland Amanda E AE Torres Diana D Truong Thérèse T Tung Nadine N Vachon Celine M CM van Asperen Christi J CJ van den Ouweland Ans M W AMW van Rensburg Elizabeth J EJ Vega Ana A Viel Alessandra A Wang Qin Q Wappenschmidt Barbara B Weitzel Jeffrey N JN Wendt Camilla C Winqvist Robert R Yang Xiaohong R XR Yannoukakos Drakoulis D Ziogas Argyrios A Kraft Peter P Antoniou Antonis C AC Zheng Wei W Easton Douglas F DF Milne Roger L RL Beesley Jonathan J Chenevix-Trench Georgia G
Nature communications 20190415 1
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several w ...[more]