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Regional HLA differences in Poland and their effect on stem cell donor registry planning.

ABSTRACT: Regional HLA frequency differences are of potential relevance for the optimization of stem cell donor recruitment. We analyzed a very large sample (n?=?123,749) of registered Polish stem cell donors. Donor figures by 1-digit postal code regions ranged from n?=?5,243 (region 9) to n?=?19,661 (region 8). Simulations based on region-specific haplotype frequencies showed that donor recruitment in regions 0, 2, 3 and 4 (mainly located in the south-eastern part of Poland) resulted in an above-average increase of matching probabilities for Polish patients. Regions 1, 7, 8, 9 (mainly located in the northern part of Poland) showed an opposite behavior. However, HLA frequency differences between regions were generally small. A strong indication for regionally focused donor recruitment efforts can, therefore, not be derived from our analyses. Results of haplotype frequency estimations showed sample size effects even for sizes between n?5,000 and n?20,000. This observation deserves further attention as most published haplotype frequency estimations are based on much smaller samples.

SUBMITTER: Schmidt AH

PROVIDER: S-EPMC3772002 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Regional HLA differences in Poland and their effect on stem cell donor registry planning.

Schmidt Alexander H AH Solloch Ute V UV Pingel Julia J Sauter Jürgen J Böhme Irina I Cereb Nezih N Dubicka Kinga K Schumacher Stephan S Wachowiak Jacek J Ehninger Gerhard G

PloS one 20130912 9

Regional HLA frequency differences are of potential relevance for the optimization of stem cell donor recruitment. We analyzed a very large sample (n = 123,749) of registered Polish stem cell donors. Donor figures by 1-digit postal code regions ranged from n = 5,243 (region 9) to n = 19,661 (region 8). Simulations based on region-specific haplotype frequencies showed that donor recruitment in regions 0, 2, 3 and 4 (mainly located in the south-eastern part of Poland) resulted in an above-average ...[more]

PMID: 24069237

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Dataset Information

Regional HLA differences in Poland and their effect on stem cell donor registry planning.

Publications

Regional HLA differences in Poland and their effect on stem cell donor registry planning.

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