Regional HLA differences in Poland and their effect on stem cell donor registry planning.
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ABSTRACT:
SUBMITTER: Schmidt AH
PROVIDER: S-EPMC3772002 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Regional HLA differences in Poland and their effect on stem cell donor registry planning.
Schmidt Alexander H AH Solloch Ute V UV Pingel Julia J Sauter Jürgen J Böhme Irina I Cereb Nezih N Dubicka Kinga K Schumacher Stephan S Wachowiak Jacek J Ehninger Gerhard G
PloS one 20130912 9
Regional HLA frequency differences are of potential relevance for the optimization of stem cell donor recruitment. We analyzed a very large sample (n = 123,749) of registered Polish stem cell donors. Donor figures by 1-digit postal code regions ranged from n = 5,243 (region 9) to n = 19,661 (region 8). Simulations based on region-specific haplotype frequencies showed that donor recruitment in regions 0, 2, 3 and 4 (mainly located in the south-eastern part of Poland) resulted in an above-average ...[more]
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