Ontology highlight
ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC3772385 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Journal of cell science 20130710 Pt 18
We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO(ob)) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO(ob) mice are thinner, with increased brittleness. Osteoblast activity is reduced as reflected in a reduced bone formation rate and failure to differentiate to a mature mineralizing stage. Bmp2 in osteoblasts also indirectly controls angiogenesis in the periosteum and bone marrow. VegfA production is reduc ...[more]