Ontology highlight
ABSTRACT:
SUBMITTER: Carroll SH
PROVIDER: S-EPMC3346096 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Carroll Shannon H SH Wigner Nathan A NA Kulkarni Nitin N Johnston-Cox Hillary H Gerstenfeld Louis C LC Ravid Katya K
The Journal of biological chemistry 20120308 19
The differentiation of osteoblasts from their precursors, mesenchymal stem cells, is an important component of bone homeostasis as well as fracture healing. The A2B adenosine receptor (A2BAR) is a Gα(s)/α(q)-protein-coupled receptor that signals via cAMP. cAMP-mediated signaling has been demonstrated to regulate the differentiation of mesenchymal stem cells (MSCs) into various skeletal tissue lineages. Here, we studied the role of this receptor in the differentiation of MSCs to osteoblasts. In v ...[more]