Ontology highlight
ABSTRACT:
SUBMITTER: Lee TI
PROVIDER: S-EPMC3773330 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Lee Tong Ihn TI Jenner Richard G RG Boyer Laurie A LA Guenther Matthew G MG Levine Stuart S SS Kumar Roshan M RM Chevalier Brett B Johnstone Sarah E SE Cole Megan F MF Isono Kyo-ichi K Koseki Haruhiko H Fuchikami Takuya T Abe Kuniya K Murray Heather L HL Zucker Jacob P JP Yuan Bingbing B Bell George W GW Herbolsheimer Elizabeth E Hannett Nancy M NM Sun Kaiming K Odom Duncan T DT Otte Arie P AP Volkert Thomas L TL Bartel David P DP Melton Douglas A DA Gifford David K DK Jaenisch Rudolf R Young Richard A RA
Cell 20060401 2
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2) subunit SUZ12 across the entire nonrepeat portion of the genome in human embryonic stem (ES) cells. We found that SUZ12 is distributed across large portions of over two hundred genes encoding key developmental regulators. These genes are occupied by nucleosomes trimethylated at histone H3K27, are tr ...[more]