Characterization of MYC-induced tumorigenesis by in situ lipid profiling.
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ABSTRACT:
SUBMITTER: Perry RH
PROVIDER: S-EPMC3773496 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Characterization of MYC-induced tumorigenesis by in situ lipid profiling.
Perry Richard H RH Bellovin David I DI Shroff Emelyn H EH Ismail Ali I AI Zabuawala Tahera T Felsher Dean W DW Zare Richard N RN
Analytical chemistry 20130418 9
We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and off has led to the discovery of highly specific lipid molecules associated with MYC-induced tumor onset. We are able to distinguish normal from MYC-induced ...[more]
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