Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC7865656 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wang Dong D Pierce Angela A Veo Bethany B Fosmire Susan S Danis Etienne E Donson Andrew A Venkataraman Sujatha S Vibhakar Rajeev R
Cancers 20210121 3
Polo-like kinase 1 (<i>PLK1</i>) is highly expressed in group 3 medulloblastoma (MB), and it has been preclinically validated as a cancer therapeutic target in medulloblastoma. Here, we demonstrate that PLK1 inhibition with PCM-075 or BI6727 significantly reduces the growth of MB cells and causes a decrease of <i>c-MYC</i> mRNA and protein levels. We show that MYC activates <i>PLK1</i> transcription, while the inhibition of PLK1 suppresses MB tumor development and causes a decrease in c-MYC prot ...[more]