Ontology highlight
ABSTRACT:
SUBMITTER: Sakata K
PROVIDER: S-EPMC3773762 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Sakata Kazuko K Martinowich Keri K Woo Newton H NH Schloesser Robert J RJ Jimenez Dennisse V DV Ji Yuanyuan Y Shen Liya L Lu Bai B
Proceedings of the National Academy of Sciences of the United States of America 20130826 37
Activity-dependent gene transcription, including that of the brain-derived neurotrophic factor (Bdnf) gene, has been implicated in various cognitive functions. We previously demonstrated that mutant mice with selective disruption of activity-dependent BDNF expression (BDNF-KIV mice) exhibit deficits in GABA-mediated inhibition in the prefrontal cortex (PFC). Here, we show that disruption of activity-dependent BDNF expression impairs BDNF-dependent late-phase long-term potentiation (L-LTP) in CA1 ...[more]