Ontology highlight
ABSTRACT:
SUBMITTER: Vater A
PROVIDER: S-EPMC3774380 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Vater Axel A Sell Simone S Kaczmarek Przemyslaw P Maasch Christian C Buchner Klaus K Pruszynska-Oszmalek Ewa E Kolodziejski Pawel P Purschke Werner G WG Nowak Krzysztof W KW Strowski Mathias Z MZ Klussmann Sven S
The Journal of biological chemistry 20130606 29
Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia in type 1 and type 2 diabetes. Accordingly, immunoneutralization of glucagon or genetic deletion of the glucagon receptor improved glucose homeostasis in animal models of diabetes. Despite this strong evidence, agents that selectively interfere with endogenous glucagon have not been implemented in clinical practice yet. We report the discovery of mirror-image DNA-aptamers (Spiegelmer®) th ...[more]