The MOV10 helicase inhibits LINE-1 mobility.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3774381 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
The MOV10 helicase inhibits LINE-1 mobility.
Li Xiaoyu X Zhang Jianyong J Jia Rui R Cheng Vicky V Xu Xin X Qiao Wentao W Guo Fei F Liang Chen C Cen Shan S
The Journal of biological chemistry 20130610 29
LINE-1 (long interspersed element 1) is an autonomous non-long terminal repeat retrotransposon. Its replication often causes mutation and rearrangement of host genomic DNA. Accordingly, host cells have evolved mechanisms to control LINE-1 mobility. Here, we report that a helicase named MOV10 effectively suppresses LINE-1 transposition. Mutating the helicase motifs impairs this function of MOV10, suggesting that MOV10 requires its helicase activity to suppress LINE-1 replication. Further studies ...[more]
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