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A DOTA-peptide conjugate by copper-free click chemistry.

ABSTRACT: Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.

SUBMITTER: Martin ME 

PROVIDER: S-EPMC3774834 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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A DOTA-peptide conjugate by copper-free click chemistry.

Martin Molly E ME   Parameswarappa Sharavathi G SG   O'Dorisio M Sue MS   Pigge F Christopher FC   Schultz Michael K MK  

Bioorganic & medicinal chemistry letters 20100625 16

Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity. ...[more]

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