Ontology highlight
ABSTRACT:
SUBMITTER: Sharma P
PROVIDER: S-EPMC3775507 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Cell reports 20130516 5
Posttranslational modification with small ubiquitin-like modifier (Sumo) regulates numerous cellular and developmental processes. Sumoylation is dynamic with deconjugation by Sumo-specific proteases (Senps) regulating steady-state levels. Different Senps are found in distinct subcellular domains, which may limit their deconjugation activity to colocalizing Sumo-modified proteins. In vitro, Senps can discriminate between the different Sumo paralogs: Sumo1 versus the highly related Sumo2 and Sumo3 ...[more]