Ontology highlight
ABSTRACT:
SUBMITTER: Crowl JT
PROVIDER: S-EPMC6042150 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Crowl John T JT Stetson Daniel B DB
Proceedings of the National Academy of Sciences of the United States of America 20180611 26
Detection of nucleic acids by innate immune sensors triggers the production of type I interferons (IFNs). While IFNs are essential for host defense against viral infection, dysregulated production of IFNs underlies numerous autoinflammatory diseases. We have found that the loss of sumoylation results in a potent, spontaneous IFN response. Vertebrates possess three small ubiquitin-like modifiers (SUMOs) that can be conjugated onto target proteins and alter protein function in diverse but still po ...[more]