Nephrons require Rho-kinase for proximal-distal polarity development.
Ontology highlight
ABSTRACT:
SUBMITTER: Lindstrom NO
PROVIDER: S-EPMC3776198 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Nephrons require Rho-kinase for proximal-distal polarity development.
Lindström Nils O NO Hohenstein Peter P Davies Jamie A JA
Scientific reports 20130101
Epithelial tubules must have the right length and pattern for proper function. In the nephron, planar cell polarity controls elongation along the proximal-distal axis. As the tubule lengthens, specialized segments (proximal, distal etc.) begin to differentiate along it. Other epithelia need Rho-kinase for planar cell polarity but it is not known whether Rho-kinase is involved in this way in the nephron. We show that Rho-kinase is essential for the morphogenesis of nephrons, specifically for corr ...[more]
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