Ontology highlight
ABSTRACT:
SUBMITTER: Virag P
PROVIDER: S-EPMC3776436 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Virag Piroska P Fischer-Fodor Eva E Perde-Schrepler Maria M Brie Ioana I Tatomir Corina C Balacescu Loredana L Berindan-Neagoe Ioana I Victor Bogdan B Balacescu Ovidiu O
BMC genomics 20130716
<h4>Background</h4>Cancer cells frequently adopt cellular and molecular alterations and acquire resistance to cytostatic drugs. Chemotherapy with oxaliplatin is among the leading treatments for colorectal cancer with a response rate of 50%, inducing intrastrand cross-links on the DNA. Despite of this drug's efficiency, resistance develops in nearly all metastatic patients. Chemoresistance being of crucial importance for the drug's clinical efficiency this study aimed to contribute to the identif ...[more]