Ontology highlight
ABSTRACT:
SUBMITTER: Noordhuis P
PROVIDER: S-EPMC6696456 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Noordhuis Paul P Laan Adrianus C AC van de Born Kasper K Honeywell Richard J RJ Peters Godefridus J GJ
International journal of molecular sciences 20190724 15
Oxaliplatin (OHP) treatment of colorectal cancer (CRC) frequently leads to resistance. OHP resistance was induced in CRC cell lines LoVo-92 and LoVo-Li and a platinum-sensitive ovarian cancer cell line, A2780, and related to cellular platinum accumulation, platinum-DNA adducts, transporter expression, DNA repair genes, gene expression arrays, and array-CGH profiling. Pulse (4 h, 4OHP) and continuous exposure (72 h, cOHP) resulted in 4.0 to 7.9-fold and 5.0 to 11.8-fold drug resistance, respectiv ...[more]