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1H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease.

ABSTRACT: 1H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR?

SUBMITTER: Joe E 

PROVIDER: S-EPMC6295351 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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<sup>1</sup>H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease.

Joe Elizabeth E   Medina Luis D LD   Ringman John M JM   O'Neill Joseph J  

Brain imaging and behavior 20190801 4

<sup>1</sup>H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-s  ...[more]

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