Ontology highlight
ABSTRACT:
SUBMITTER: Fujiki K
PROVIDER: S-EPMC3777410 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Fujiki Kotoyo K Duerr Eva-Maria EM Kikuchi Hirotoshi H Ng Aylwin A Xavier Ramnik J RJ Mizukami Yusuke Y Imamura Takaaki T Kulke Matthew H MH Chung Daniel C DC
Gastroenterology 20080723 3
<h4>Background & aims</h4>The molecular alterations that underlie carcinoid tumor pathogenesis remain poorly defined. The homeobox gene HOXC6 was highly up-regulated in human gastrointestinal carcinoid tumors, and we sought to define its pathogenic role.<h4>Methods</h4>The functional and physical properties of Hoxc6 were investigated by establishing carcinoid cells that stably overexpressed Hoxc6 or were deficient in Hoxc6. Cellular proliferation assays, luciferase reporter assays, Western blott ...[more]