Role of ABC transporters in cancer chemotherapy.
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ABSTRACT:
SUBMITTER: Sun YL
PROVIDER: S-EPMC3777472 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Role of ABC transporters in cancer chemotherapy.
Sun Yue-Li YL Patel Atish A Kumar Priyank P Chen Zhe-Sheng ZS
Chinese journal of cancer 20120117 2
Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findin ...[more]
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