Thermodynamics of ABC transporters.
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ABSTRACT:
SUBMITTER: Zhang XC
PROVIDER: S-EPMC4707154 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Thermodynamics of ABC transporters.
Zhang Xuejun C XC Han Lei L Zhao Yan Y
Protein & cell 20150925 1
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic confo ...[more]
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