Ontology highlight
ABSTRACT:
SUBMITTER: Vogel-Ciernia A
PROVIDER: S-EPMC3777648 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Vogel-Ciernia Annie A Matheos Dina P DP Barrett Ruth M RM Kramár Enikö A EA Azzawi Soraya S Chen Yuncai Y Magnan Christophe N CN Zeller Michael M Sylvain Angelina A Haettig Jakob J Jia Yousheng Y Tran Anthony A Dang Richard R Post Rebecca J RJ Chabrier Meredith M Babayan Alex H AH Wu Jiang I JI Crabtree Gerald R GR Baldi Pierre P Baram Tallie Z TZ Lynch Gary G Wood Marcelo A MA
Nature neuroscience 20130324 5
Recent exome sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human intellectual disabilities and cognitive disorders. However, it is currently unknown how mutations in BAF complexes result in impaired cognitive function. Postmitotic neurons express a neuron-specific assembly, nBAF, characterized by the neuron-specific subunit BAF53b. Mice harboring selective genetic manipulations of BAF53b have se ...[more]