Ontology highlight
ABSTRACT:
SUBMITTER: Xavier MN
PROVIDER: S-EPMC3777723 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Xavier Mariana N MN Winter Maria G MG Spees Alanna M AM den Hartigh Andreas B AB Nguyen Kim K Roux Christelle M CM Silva Teane M A TM Atluri Vidya L VL Kerrinnes Tobias T Keestra A Marijke AM Monack Denise M DM Luciw Paul A PA Eigenheer Richard A RA Bäumler Andreas J AJ Santos Renato L RL Tsolis Renée M RM
Cell host & microbe 20130801 2
Eradication of persistent intracellular bacterial pathogens with antibiotic therapy is often slow or incomplete. However, strategies to augment antibiotics are hampered by our poor understanding of the nutritional environment that sustains chronic infection. Here we show that the intracellular pathogen Brucella abortus survives and replicates preferentially in alternatively activated macrophages (AAMs), which are more abundant during chronic infection. A metabolic shift induced by peroxisome pro ...[more]