Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages.

ABSTRACT: Cellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells. As a consequence, cells surrounding tumors are eliminated and engulfed by macrophages. We propose a novel scenario in which circulating cells facing a tumor can reproduce these cellular interactions. In vitro cultured macrophages from murine bone marrow were used to investigate this hypothesis. M1 macrophages in tumoral medium upregulated markers of a suboptimal condition, such as Sparc and TyrRS, and undergo apoptosis. However, M2 macrophages display higher Myc expression levels and proliferate at the expense of M1. Resulting M1 apoptotic

SUBMITTER: Lolo FN 

PROVIDER: S-EPMC5769648 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature