Ontology highlight
ABSTRACT:
SUBMITTER: Lolo FN
PROVIDER: S-EPMC5769648 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Lolo Fidel-Nicolás FN Rius Cristina C Casas-Tintó Sergio S
Biology open 20171215 12
Cellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells. As a consequence, cells surrounding tumors are eliminated and engulfed by macrophages. We propose a novel scenario in which circulating cells facing a tumor can reproduce these cellular interactions. <i>In vitro</i> cultured macrophages from murine bone marrow were used to ...[more]