Ontology highlight
ABSTRACT:
SUBMITTER: Cho BK
PROVIDER: S-EPMC3777760 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Nature chemical biology 20111113 1
Although metabolic networks have been reconstructed on a genome scale, the corresponding reconstruction and integration of governing transcriptional regulatory networks has not been fully achieved. Here we reconstruct such an integrated network for amino acid metabolism in Escherichia coli. Analysis of ChIP-chip and gene expression data for the transcription factors ArgR, Lrp and TrpR showed that 19 out of 20 amino acid biosynthetic pathways are either directly or indirectly controlled by these ...[more]