Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC3778154 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Kim Sung Joon SJ Tanaka Kelly S E KS Dietrich Evelyne E Rafai Far Adel A Schaefer Jacob J
Biochemistry 20130508 20
Glycopeptides whose aminosugars have been modified by attachment of hydrophobic side chains are frequently active against vancomycin-resistant microorganisms. We have compared the conformations of six such fluorinated glycopeptides (with side chains of varying length) complexed to cell walls labeled with d-[1-(13)C]alanine, [1-(13)C]glycine, and l-[ε-(15)N]lysine in whole cells of Staphylococcus aureus. The internuclear distances from (19)F of the bound drug to the (13)C and (15)N labels of the ...[more]