Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC3143575 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lu Jianli J Hua Zhengmao Z Kobertz William R WR Deutsch Carol C
Journal of molecular biology 20110601 2
Although we have numerous structures of ribosomes, none disclose side-chain rearrangements of the nascent peptide during chain elongation. This study reports for the first time that rearrangement of the peptide and/or tunnel occurs in distinct regions of the tunnel and is directed by the unique primary sequence of each nascent peptide. In the tunnel mid-region, the accessibility of an introduced cysteine to a series of novel hydrophilic maleimide reagents increases with increasing volume of the ...[more]