Ontology highlight
ABSTRACT:
SUBMITTER: Koethe JR
PROVIDER: S-EPMC3778969 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20130721 8
Human immunodeficiency virus type 1 (HIV) infection and antiretroviral therapy (ART) have long been associated with abnormalities in adipose tissue distribution and metabolism. More-recent evidence demonstrates that adipocytes and adipose-resident immune cells have a role in the response to HIV. Clinical and laboratory studies indicate that viral proteins and antiretroviral medications alter adipocyte biology to enhance the persistent, systemic inflammatory state characteristic of untreated and ...[more]