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Local acetate inhibits brown adipose tissue function.

ABSTRACT: Brown adipose tissue has been extensively studied in the last decade for its potential to counteract the obesity pandemic. However, the paracrine regulation within brown tissue is largely unknown. Here, we show that local acetate directly inhibits brown fat thermogenesis, without changing acetate levels in the circulation. We demonstrate that modulating acetate within brown tissue at physiological levels blunts its function and systemically decreases energy expenditure. Using a series of transcriptomic analyses, we identified genes related to the tricarboxylic acid cycle and brown adipocyte formation, which are down-regulated upon local acetate administration. Overall, these findings demonstrate that local acetate inhibits brown fat function.

SUBMITTER: Sun W

PROVIDER: S-EPMC8670478 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Local acetate inhibits brown adipose tissue function.

Sun Wenfei W Dong Hua H Wolfrum Christian C

Proceedings of the National Academy of Sciences of the United States of America 20211201 49

Brown adipose tissue has been extensively studied in the last decade for its potential to counteract the obesity pandemic. However, the paracrine regulation within brown tissue is largely unknown. Here, we show that local acetate directly inhibits brown fat thermogenesis, without changing acetate levels in the circulation. We demonstrate that modulating acetate within brown tissue at physiological levels blunts its function and systemically decreases energy expenditure. Using a series of transcr ...[more]

PMID: 34845033

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