MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells.

ABSTRACT:

Background

MicroRNAs (miRNAs) are increasingly being recognized as being involved in cancer development and progression in gliomas.

Methods

Using a model cell system developed in our lab to study glioma progression comprising human neuroglial culture (HNGC)-1 and HNGC-2 cells, we report here that miR-145 is one of the miRNAs significantly downregulated during malignant transformation in glioblastoma multiforme (GBM). In a study using tumor samples derived from various glioma grades, we show that expression of miR-145 is decreased in a graded manner, with GBM patients showing lowest expression relative to lower-grade gliomas (P < .05) and normal brain tissues (P < .0001). Functional studies involving ectopic expression of miR-145 in glioma cells had a negative impact on cell

SUBMITTER: Rani SB 

PROVIDER: S-EPMC3779040 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature