Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez A
PROVIDER: S-EPMC3779525 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Fernandez Anna A Matias Núria N Fucho Raquel R Ribas Vicente V Von Montfort Claudia C Nuño Natalia N Baulies Anna A Martinez Laura L Tarrats Núria N Mari Montserrat M Colell Anna A Morales Albert A Dubuquoy Laurent L Mathurin Philippe P Bataller Ramón R Caballeria Joan J Elena Montserrat M Balsinde Jesus J Kaplowitz Neil N Garcia-Ruiz Carmen C Fernandez-Checa Jose C JC
Journal of hepatology 20130523 4
<h4>Background & aims</h4>The pathogenesis of alcohol-induced liver disease (ALD) is poorly understood. Here, we examined the role of acid sphingomyelinase (ASMase) in alcohol induced hepatic endoplasmic reticulum (ER) stress, a key mechanism of ALD.<h4>Methods</h4>We examined ER stress, lipogenesis, hyperhomocysteinemia, mitochondrial cholesterol (mChol) trafficking and susceptibility to LPS and concanavalin-A in ASMase(-)(/-) mice fed alcohol.<h4>Results</h4>Alcohol feeding increased SREBP-1c, ...[more]