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Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events.

ABSTRACT: Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus. Genomes of two recent field strains provide a clue to its adaptation to the new host: recombination of a NF-I binding site motif, which is required for efficient viral replication, from another HAdV genome. This motif is absent in the chimpanzee adenoviruses and the HAdV-E4 prototype, but is conserved amongst other HAdVs. This is the first report of an interspecies recombination event for HAdVs, and the first documentation of a lateral partial gene transfer from a chimpanzee AdV. The potential for such recombination events are important when considering chimpanzee adenoviruses as candidate gene delivery vectors for human patients.

SUBMITTER: Dehghan S

PROVIDER: S-EPMC3779658 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events.

Dehghan Shoaleh S Seto Jason J Liu Elizabeth B EB Walsh Michael P MP Dyer David W DW Chodosh James J Seto Donald D

Virology 20130610 2

Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus. Genomes of two recent field strains provide a clue to its adaptation to the new host: recombination of a NF-I binding site motif, which is required for efficient viral replication ...[more]

PMID: 23763770

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Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events.

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Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events.

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