Detection of homologous recombination events in bacterial genomes.
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ABSTRACT:
SUBMITTER: Wang WB
PROVIDER: S-EPMC3792089 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Detection of homologous recombination events in bacterial genomes.
Wang Wei-Bung WB Jiang Tao T Gardner Shea S
PloS one 20131007 10
We study the detection of mutations, sequencing errors, and homologous recombination events (HREs) in a set of closely related microbial genomes. We base the model on single nucleotide polymorphisms (SNPs) and break the genomes into blocks to handle the rearrangement problem. Then we apply a dynamic programming algorithm to model whether changes within each block are likely a result of mutations, sequencing errors, or HREs. Results from simulation experiments show that we can detect 31%-61% of H ...[more]
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