Ontology highlight
ABSTRACT:
SUBMITTER: Roeder AM
PROVIDER: S-EPMC3779759 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Roeder Andreas M AM Roettger Yvonne Y Stündel Anne A Dodel Richard R Geyer Armin A
The Journal of biological chemistry 20130711 38
Covalently linked carboxyl-terminal segments of the β-amyloid peptide (Aβ) were tested for their qualification as minimal conformational epitopes of the naturally occurring human autoantibodies against β-amyloid (nAbs-Aβ). nAbs-Aβ specifically recognize the toxic oligomers of Aβ and not the monomeric or the fibrillar forms of Aβ. The synthetic dimers of Aβ(28-40) described herein mimic the toxic Aβ oligomers but are not kinetic intermediates with uncertain compositions. CD spectra identified a s ...[more]