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Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides.


ABSTRACT: Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

SUBMITTER: Wang P 

PROVIDER: S-EPMC6193484 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides.

Wang Peng P   Lo Cascio Filippa F   Gao Jia J   Kayed Rakez R   Huang Xuefei X  

Chemical communications (Cambridge, England) 20180901 72


Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity. ...[more]

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