Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC3780403 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Chen Xiaorui X Ni Fengyun F Tian Xia X Kondrashkina Elena E Wang Qinghua Q Ma Jianpeng J
Cell reports 20130530 6
Spontaneous nucleation of actin is very inefficient in cells. To overcome this barrier, cells have evolved a set of actin filament nucleators to promote rapid nucleation and polymerization in response to specific stimuli. However, the molecular mechanism of actin nucleation remains poorly understood. This is hindered largely by the fact that actin nucleus, once formed, rapidly polymerizes into filament, thus making it impossible to capture stable multisubunit actin nucleus. Here, we report an ef ...[more]