Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka K
PROVIDER: S-EPMC5945598 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature communications 20180510 1
Actin depolymerizing factor (ADF) and cofilin accelerate actin dynamics by severing and disassembling actin filaments. Here, we present the 3.8 Å resolution cryo-EM structure of cofilactin (cofilin-decorated actin filament). The actin subunit structure of cofilactin (C-form) is distinct from those of F-actin (F-form) and monomeric actin (G-form). During the transition between these three conformations, the inner domain of actin (subdomains 3 and 4) and the majority of subdomain 1 move as two sep ...[more]