Ontology highlight
ABSTRACT:
SUBMITTER: Turner ST
PROVIDER: S-EPMC3780966 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Turner Stephen T ST Boerwinkle Eric E O'Connell Jeffrey R JR Bailey Kent R KR Gong Yan Y Chapman Arlene B AB McDonough Caitrin W CW Beitelshees Amber L AL Schwartz Gary L GL Gums John G JG Padmanabhan Sandosh S Hiltunen Timo P TP Citterio Lorena L Donner Kati M KM Hedner Thomas T Lanzani Chiara C Melander Olle O Saarela Janna J Ripatti Samuli S Wahlstrand Björn B Manunta Paolo P Kontula Kimmo K Dominiczak Anna F AF Cooper-DeHoff Rhonda M RM Johnson Julie A JA
Hypertension (Dallas, Tex. : 1979) 20130610 2
To identify novel genes influencing blood pressure response to thiazide diuretic therapy for hypertension, we conducted genome-wide association meta-analyses of ≈1.1 million single-nucleotide polymorphisms in a combined sample of 424 European Americans with primary hypertension treated with hydrochlorothiazide from the Pharmacogenomic Evaluation of Antihypertensive Responses study (n=228) and the Genetic Epidemiology of Responses to Antihypertensive study (n=196). Polymorphisms associated with b ...[more]