Ontology highlight
ABSTRACT:
SUBMITTER: Duarte JD
PROVIDER: S-EPMC3360116 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Duarte J D JD Turner S T ST Tran B B Chapman A B AB Bailey K R KR Gong Y Y Gums J G JG Langaee T Y TY Beitelshees A L AL Cooper-Dehoff R M RM Boerwinkle E E Johnson J A JA
The pharmacogenomics journal 20120221 3
A recent genome-wide analysis discovered an association between a haplotype (from rs317689/rs315135/rs7297610) on Chromosome 12q15 and blood pressure response to hydrochlorothiazide (HCTZ) in African-Americans. Our aim was to replicate this association and investigate possible functional mechanisms. We observed similar associations between this haplotype and HCTZ response in an independent sample of 746 Caucasians and African-Americans randomized to HCTZ or atenolol treatment. The haplotype asso ...[more]