Ontology highlight
ABSTRACT:
SUBMITTER: Hein R
PROVIDER: S-EPMC3781176 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Hein Rebecca R Flesch-Janys Dieter D Dahmen Norbert N Beckmann Lars L Lindström Sara S Schoof Nils N Czene Kamila K Mittelstraß Kirstin K Illig Thomas T Seibold Petra P Behrens Sabine S Humphreys Keith K Li Jingmei J Liu Jianjun J Olson Janet E JE Wang Xianshu X Hankinson Susan E SE Truong Thérèse T Menegaux Florence F Dos Santos Silva Isabel I Johnson Nichola N Chen Shou-Tung ST Yu Jyh-Cherng JC Ziogas Argyrios A Kataja Vesa V Kosma Veli-Matti VM Mannermaa Arto A Anton-Culver Hoda H Shen Chen-Yang CY Brauch Hiltrud H Peto Julian J Guénel Pascal P Kraft Peter P Couch Fergus J FJ Easton Douglas F DF Hall Per P Chang-Claude Jenny J
Breast cancer research and treatment 20130220 2
Menopausal hormone therapy (MHT) is associated with an elevated risk of breast cancer in postmenopausal women. To identify genetic loci that modify breast cancer risk related to MHT use in postmenopausal women, we conducted a two-stage genome-wide association study (GWAS) with replication. In stage I, we performed a case-only GWAS in 731 invasive breast cancer cases from the German case-control study Mammary Carcinoma Risk Factor Investigation (MARIE). The 1,200 single nucleotide polymorphisms ( ...[more]