Ontology highlight
ABSTRACT:
SUBMITTER: Martin DP
PROVIDER: S-EPMC3781179 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Martin David P DP Hann Zachary S ZS Cohen Seth M SM
Inorganic chemistry 20130524 21
An ever-increasing number of metalloproteins are being discovered that play essential roles in physiological processes. Inhibitors of these proteins have significant potential for the treatment of human disease, but clinical success of these compounds has been limited. Herein, zinc(II)-dependent metalloprotein inhibitors in clinical use are reviewed, and the potential for using novel metal-binding groups (MBGs) in the design of these inhibitors is discussed. By using human carbonic anhydrase II ...[more]