Ontology highlight
ABSTRACT:
SUBMITTER: Mahendran Y
PROVIDER: S-EPMC3781437 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Mahendran Yuvaraj Y Vangipurapu Jagadish J Cederberg Henna H Stancáková Alena A Pihlajamäki Jussi J Soininen Pasi P Kangas Antti J AJ Paananen Jussi J Civelek Mete M Saleem Niyas K NK Pajukanta Päivi P Lusis Aldons J AJ Bonnycastle Lori L LL Morken Mario A MA Collins Francis S FS Mohlke Karen L KL Boehnke Michael M Ala-Korpela Mika M Kuusisto Johanna J Laakso Markku M
Diabetes 20130404 10
We investigated the association of the levels of ketone bodies (KBs) with hyperglycemia and with 62 genetic risk variants regulating glucose levels or type 2 diabetes in the population-based Metabolic Syndrome in Men (METSIM) study, including 9,398 Finnish men without diabetes or newly diagnosed type 2 diabetes. Increasing fasting and 2-h plasma glucose levels were associated with elevated levels of acetoacetate (AcAc) and β-hydroxybutyrate (BHB). AcAc and BHB predicted an increase in the glucos ...[more]